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What if we could fight cancer with a smarter, more flexible therapy, one that doesn’t rely on harsh chemo or risky cell-based treatments, but instead uses a powerful, adaptable, and fully modular system that not only targets any cancer but also exposes it to the body’s natural immune defenses?
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<aside> 2️⃣
The principal gap in knowledge is the absence of a fully modular molecular platform that is capable of simulating and outperform the cell-based immunotherapies in recognizing and killing cancer cells, while simultaneously exposing them to the immune system, without the associated risks of immune rejection and the need for lymphodepleting chemotherapy.
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I hypothesize that molecularly engineered extracellular vesicles (EVs) can be developed to carry the immune signature of natural immune cells, while being specifically directed toward cancer cells through the incorporation of chimeric antigen receptor (CAR) proteins. These EVs, enhanced with lethal signals and microRNAs or immune checkpoint inhibitors, will not only kill cancer cells but also expose them to the native immune system for improved recognition and destruction.
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